Substantive scientific letter writing is a cost-effective mode of complementing observational and experimental research. The value of such philosophically uncommitted and unsponsored well-balanced scientific activity has been relegated. Critical letter writing entails the abilities to: maintain rational scepticism; refuse to conform in order to explain data; persist in keeping common sense centre-stage; exercise logic to evaluate the biological significance of mathematical figures, including statistics, and the ability to sustain the will to share insights regarding disease mechanisms on an ostensibly lower (...) research platform. During peer review, innovative letter writing may share the occasionally unfortunate fate of innovative research. Rejected scientific letters do not automatically lose copyright. Periodicals with high letter loads will see some valuable contributions wasted, but that is the price for maintaining autonomy in scientific publication. The scientific community is an integrated whole that must respect the rights of authors at all levels. Unauthorised forwarding of rejected letters sets the dangerous precedent of justifying unjust means. (shrink)

Regulation of microtubule (MT) dynamics is essential for many cellular processes, but the machinery that controls MT dynamics remains poorly understood. MT plus‐end tracking proteins (+TIPs) are a set of MT‐associated proteins that dynamically track growing MT ends and are uniquely positioned to govern MT dynamics. +TIPs associate with each other in a complex array of inter‐ and intra‐molecular interactions known as the “+TIP network.” Why do so many +TIPs bind to other +TIPs? Typical answers include the ideas that these (...) interactions localize proteins where they are needed, deliver proteins to the cortex, and/or create regulatory pathways. We propose an additional and more mechanistic hypothesis: that +TIPs bind each other to create a superstructure that promotes MT assembly by constraining the structural fluctuations of the MT tip, thus acting as a polymerization chaperone. (shrink)

The Yogārṇava is a Sanskrit compendium on yoga that has not been published, translated or even mentioned in secondary literature on yoga. Citations attributed to it occur in several premodern commentaries and compendiums on yoga, and a few published library catalogues report manuscripts of a work on yoga called the Yogārṇava. This article presents the results of the first academic study of the text. It has attempted to answer basic questions, such as the work’s provenance and textual sources. The authors (...) then discuss the importance of the Yogārṇava within the broader history of yoga based on their identification of citations and parallel verses in other Sanskrit texts and a detailed analysis of the Yogārṇava’s content. (shrink)

The science of man, by A. Schaff.--The humanistic meaning of natural science, by R. Mukerjee.--The role of social sciences in the struggle for progress, by R. Schlesinger.--Scientific research in developing countries, by J. D. Bernal.--Problems of science and technology in underdeveloped countries by, D. D. Kosambi.--Priorities in scientific research for economic development, by J. Bognar.--Science and technology in underdeveloped countries, by S. H. Zaheer.--Science and scientific workers, by E. Olszewski.--Medical research in developing countries, by C. G. Pandit & N. P. (...) Gupta.--Changing society and crisis of enterprise, by Z. Tanic.--The university and society, by E. G. Edwards.--The intellectual and society, by V. B. Singh.--Indo-Soviet relations in retrospect, by K. P. S. Menon.--Fifteen years of cooperation between Indian and Soviet paediatricians, by I. N. Ussov. (shrink)

Книга является едва ли не первой попыткой отрефлектировать, как происходило становление философского самосознания в России.

In this letter we demonstrate that the fermionic zero modes on a superconducting domain wall can be associated to an one dimensional \ supersymmetry that contains non-trivial topological charges. In addition, the system also possesses three distinct \ supersymmetries with non-trivial topological charges and we also study some duality transformations of the supersymmetric algebras.

The volume presents a set of invited papers based on analyses of legal discourse drawn from a number of international contexts where often the English language ...

A stable classification of practical principles into mutually exclusive types is foundational to Kant’s moral theory. Yet, other than a few brief hints on the distinction between maxims and laws, he does not provide any elaborate discussion on the classification and the types of practical principles in his works. This has led Onora O’Neill and Lewis Beck to reinterpret Kant’s classification of practical principles in a way that would clarify the conceptual connection between maxims and laws. In this paper I (...) argue that the revised interpretations of O’Neill and Beck stem from a mistaken reading of the fundamental basis of the classification of practical principles. To show this, I first argue that Kant distinguishes between maxims and laws on the bases of validity and reality. I then argue that although a practical principle necessarily has the feature of validity, its reality in actually moving the agents to action sufficiently makes a principle a practical principle. If this is so, I argue that the classification of practical principles must be based on the extent to which they are effective in human agents. Such a classification yields us three exhaustive and mutually exclusive types namely, “maxims that are not potential laws”, “maxims that are potential laws” and “laws that are not maxims”. (shrink)